SHC3
SHC3 (SHC adaptor protein 3) هوَ بروتين يُشَفر بواسطة جين SHC3 في الإنسان.[1][2]
الوظيفة[عدل]
![[أيقونة]](%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية[عدل]
| هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع[عدل]
- ^ Nakamura T؛ Sanokawa R؛ Sasaki Y؛ Ayusawa D؛ Oishi M؛ Mori N (نوفمبر 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. ج. 13 ع. 6: 1111–21. PMID:8808684.
- ^ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3". مؤرشف من الأصل في 2010-12-05.
قراءة متعمقة[عدل]
- O'Bryan JP، Songyang Z، Cantley L، وآخرون (1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain". Proc. Natl. Acad. Sci. U.S.A. ج. 93 ع. 7: 2729–34. Bibcode:1996PNAS...93.2729O. DOI:10.1073/pnas.93.7.2729. PMC:39699. PMID:8610109.
- Pelicci G، Dente L، De Giuseppe A، وآخرون (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. ج. 13 ع. 3: 633–41. PMID:8760305.
- Menegon A؛ Leoni C؛ Benfenati F؛ Valtorta F (1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum". Biochem. Biophys. Res. Commun. ج. 238 ع. 3: 800–5. DOI:10.1006/bbrc.1997.7393. PMID:9325171.
- Wang JF، Ganju RK، Liu ZY، وآخرون (1997). "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood. ج. 90 ع. 9: 3507–15. PMID:9345034.
- Nakamura T؛ Muraoka S؛ Sanokawa R؛ Mori N (1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. ج. 273 ع. 12: 6960–7. DOI:10.1074/jbc.273.12.6960. PMID:9507002.
- Cook KK؛ Fadool DA (2002). "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase". J. Biol. Chem. ج. 277 ع. 15: 13268–80. DOI:10.1074/jbc.M108898200. PMC:2779217. PMID:11812778.
- Tarr PE، Roncarati R، Pelicci G، وآخرون (2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc". J. Biol. Chem. ج. 277 ع. 19: 16798–804. DOI:10.1074/jbc.M110286200. PMID:11877420.
- Liu HY؛ Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. ج. 277 ع. 29: 26046–56. DOI:10.1074/jbc.M111659200. PMID:12006576.
- Miyake I، Hakomori Y، Shinohara A، وآخرون (2002). "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines". Oncogene. ج. 21 ع. 38: 5823–34. DOI:10.1038/sj.onc.1205735. PMID:12185581.
- Pelicci G، Troglio F، Bodini A، وآخرون (2002). "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway". Mol. Cell. Biol. ج. 22 ع. 20: 7351–63. DOI:10.1128/MCB.22.20.7351-7363.2002. PMC:139827. PMID:12242309.
- Nakamura T، Komiya M، Sone K، وآخرون (2003). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. ج. 22 ع. 24: 8721–34. DOI:10.1128/MCB.22.24.8721-8734.2002. PMC:139861. PMID:12446789.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
- Miyake I، Hakomori Y، Misu Y، وآخرون (2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells". Oncogene. ج. 24 ع. 19: 3206–15. DOI:10.1038/sj.onc.1208523. PMID:15735675.
- Magrassi L، Conti L، Lanterna A، وآخرون (2005). "Shc3 affects human high-grade astrocytomas survival". Oncogene. ج. 24 ع. 33: 5198–206. DOI:10.1038/sj.onc.1208708. PMID:15870690.
- De Falco V، Guarino V، Malorni L، وآخرون (2005). "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors". Oncogene. ج. 24 ع. 41: 6303–13. DOI:10.1038/sj.onc.1208776. PMID:15940252.
- Toschi E، Bacigalupo I، Strippoli R، وآخرون (2006). "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway". Mol. Biol. Cell. ج. 17 ع. 4: 1985–94. DOI:10.1091/mbc.E05-08-0717. PMC:1415297. PMID:16436505.
- Li MD، Sun D، Lou XY، وآخرون (2007). "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence". Mol. Psychiatry. ج. 12 ع. 5: 462–73. DOI:10.1038/sj.mp.4001933. PMID:17179996.
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