| # | Date | Film | Gross (USD) | Openings in the top ten |
| 1 | January 9, 2022 | Spider-Man: No Way Home | $2,980,319 | My Hero Academia: World Heroes' Mission (#3), The 355 (#6), Row 19 (#7) |
| 2 | January 16, 2022 | $1,565,893 | Scream (#2), Spencer (#4) |
| 3 | January 23, 2022 | $918,265 | Jack in the Box (#4), Benedetta (#7), Belle (#10) |
| 4 | January 30, 2022 | Nightmare Alley | $847,884 | The Call (#5), Pil's Adventures (#6) |
| 5 | February 6, 2022 | Moonfall | $1,164,018 | The Medium (#5), Fireheart (#8), Jackass Forever (#9) |
| 6 | February 13, 2022 | Marry Me | $630,000 | Death on the Nile (#4), The Exorcism of God (#6), The Beatles: Get Back – The Rooftop Concert (#10) |
| 7 | February 20, 2022 | Uncharted | $2,400,000 | ¡Qué despadre! (#2) |
| 8 | February 27, 2022 | $1,538,393 | Digimon Adventure: Last Evolution Kizuna (#4), The Reckoning (#6) |
| 9 | March 6, 2022 | The Batman | $11,727,980 | |
| 10 | March 13, 2022 | $8,233,601 | Blacklight (#2), Cuarentones (#5), Sword Art Online Progressive: Aria of a Starless Night (#7), Hall (#8), Belfast (#10) |
| 11 | March 20, 2022 | $4,169,593 | The Bad Guys (#2), Ambulance (#3), The Worst Person in the World (#7) |
| 12 | March 27, 2022 | $1,806,964 | Jujutsu Kaisen 0 (#2), The Protégé (#5), See for Me (#7) |
| 13 | April 3, 2022 | Morbius | $3,787,631 | Dos más dos (#6) |
| 14 | April 10, 2022 | Sonic the Hedgehog 2 | $8,139,877 | ¿Y cómo es él? (#3), The Desperate Hour (#6) |
| 15 | April 17, 2022 | Fantastic Beasts: The Secrets of Dumbledore | $7,264,919 | The Northman (#5), Behind You (#8) |
| 16 | April 24, 2022 | $3,972,808 | The Lost City (#3), Sin ti no puedo (#10) |
| 17 | May 1, 2022 | Sonic the Hedgehog 2 | $2,667,216 | La Abuela (#5), The Unbearable Weight of Massive Talent (#9) |
| 18 | May 8, 2022 | Doctor Strange in the Multiverse of Madness | $20,884,093 | |
| 19 | May 15, 2022 | $10,259,850 | Memory (#3), Firestarter (#6), La Nave (#8) |
| 20 | May 22, 2022 | $4,682,072 | Dog (#4), Jurassic Park Re-release (#8), Father Stu (#10) |
| 21 | May 29, 2022 | Top Gun: Maverick | $5,550,409 | X (#7) |
| 22 | June 5, 2022 | Jurassic World Dominion | $18,127,000 | La Civil (#9) |
| 23 | June 12, 2022 | $12,128,362 | Diavlo (#4), The Colony (#6), Everything Everywhere All at Once (#7), Ride Like a Girl (#10) |
| 24 | June 19, 2022 | Lightyear | $7,813,598 | |
| 25 | June 26, 2022 | $6,611,878 | The Black Phone (#3), Adieu Monsieur Haffmann (#8), Tout Nous Sourit (#9) |
| 26 | July 3, 2022 | Minions: The Rise of Gru | $12,709,736 | |
| 27 | July 10, 2022 | Thor: Love and Thunder | $11,630,259 | I'm Your Man (#8) |
| 28 | July 17, 2022 | $7,473,403 | Elvis (#4), The Twin (#6) |
| 29 | July 24, 2022 | Minions: The Rise of Gru | $4,213,237 | Shut In (#7), Un Retrato de Familia (#8) |
| 30 | July 31, 2022 | $2,897,412 | DC League of Super-Pets (#3), The Ledge (#6), Martyrs Lane (#7), Good Luck to You, Leo Grande (#9) |
| 31 | August 7, 2022 | Bullet Train | $3,000,000 | |
| 32 | August 14, 2022 | $2,300,000 | Beast (#2), Paws of Fury: The Legend of Hank (#6) |
| 33 | August 21, 2022 | Dragon Ball Super: Super Hero | $3,700,000 | The Cellar (#5) |
| 34 | August 28, 2022 | $2,214,952 | Nope (#3), After Ever Happy (#7) |
| 35 | September 4, 2022 | $898,279 | Fall (#3), Spider-Man: No Way Home - The More Fun Stuff Version (#5), Where the Crawdads Sing (#6), Lecciones para Canallas (#9) |
| 36 | September 11, 2022 | Fall | $1,295,883 | Soy tu Fan (#2), The Invitation (#7) |
| 37 | September 18, 2022 | Orphan: First Kill | $2,308,040 | Tadeo El Explorador 3: La Maldición de la Momia (#2), Cuando Sea Joven (#4), Barbarian (#10) |
| 38 | September 25, 2022 | $2,192,942 | Avatar (Re-release) (#2), Don't Worry Darling (#3), Mal de Ojo (#5) |
| 39 | October 2, 2022 | Smile | $2,029,665 | Emergency Declaration (#5), Águila y Jaguar: Guerreros Legendarios (#8), Till Death (#10) |
| 40 | October 9, 2022 | $2,652,756 | Ticket to Paradise (#2), Last Seen Alive (#5), Amsterdam (#8) |
| 41 | October 16, 2022 | Halloween Ends | $2,977,235 | The Woman King (#4), Gulliver Returns (#7) |
| 42 | October 23, 2022 | Black Adam | $5,867,734 | The Boy Behind the Door (#7) |
| 43 | October 30, 2022 | $4,101,090 | Prey for the Devil (#2), Lyle, Lyle, Crocodile (#3), Hard Hit (#7), Bros (#10) |
| 44 | November 6, 2022 | $3,483,880 | One Piece Film: Red (#2), La Exorcista (#5), Mrs. Harris Goes to Paris (#9) |
| 45 | November 13, 2022 | Black Panther: Wakanda Forever | $13,181,250 | |
| 46 | November 20, 2022 | $10,010,544 | Jeepers Creepers: Reborn (#3), The Menu (#4), The Cursed: Dead Man's Prey (#6), The Twilight Saga (Re-release) (#7), Ojos Que No Ven (#8) |
| 47 | November 27, 2022 | $6,279,309 | Strange World (#2), El Poderoso Victoria (#6), Kandisha (#8) |
| 48 | December 4, 2022 | $3,003,826 | Violent Night (#3), The North Sea (#4), Devotion (#9) |
| 49 | December 11, 2022 | $1,176,967 | Puss in Boots: The Last Wish (#2), Shark Bait (#6), Letto Numero 6 (#8), Tre Nøtter Til Askepott (#10) |
| 50 | December 18, 2022 | Avatar: The Way of Water | $15,645,027 | |
| 51 | December 25, 2022 | $12,047,011 | A Man Called Otto (#4), Mi Suegra Me Odia (#5) |
| 52 | January 1, 2023 | $11,120,394 | M3GAN (#3), Malvada (#7) |
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