| # | Date | Film | Gross (USD) | Openings in the top ten |
| 1 | January 5, 2003 | Catch Me If You Can | $2,411,291 | |
| 2 | January 12, 2003 | My Big Fat Greek Wedding | $1,609,627 | Fear dot com (#7), Jackass: The Movie (#8), The Banger Sisters (#10) |
| 3 | January 19, 2003 | La hija del caníbal | $1,541,742 | 8 Mile (#3), Simone (#8) |
| 4 | January 26, 2003 | Sweet Home Alabama | $1,135,407 | Star Trek: Nemesis (#10) |
| 5 | February 2, 2003 | Gangs of New York | $2,092,610 | Abandon (#10) |
| 6 | February 9, 2003 | Just Married | $1,303,665 | |
| 7 | February 16, 2003 | Two Weeks Notice | $1,645,751 | I Spy (#3) |
| 8 | February 23, 2003 | $1,100,269 | Empire (#6), La Mano del Zurdo (#7), Belphégor - Le fantôme du Louvre (#9), Adaptation (#10) |
| 9 | March 2, 2003 | Chicago | $1,261,153 | Analyze That (#4), Ballistic: Ecks vs. Sever (#5) |
| 10 | March 9, 2003 | Maid in Manhattan | $1,177,784 | The Hours (#5), The Life of David Gale (#6) |
| 11 | March 16, 2003 | Daredevil | $2,736,749 | About Schmidt (#4) |
| 12 | March 23, 2003 | Kangaroo Jack | $1,510,795 | The Recruit (#3), The Pianist (#4) |
| 13 | March 30, 2003 | The Hot Chick | $1,730,615 | The Core (#2), Half Past Dead (#8), Far from Heaven (#9) |
| 14 | April 6, 2003 | $1,436,076 | Tears of the Sun (#2), Final Destination 2 (#5), The Four Feathers (#9) |
| 15 | April 13, 2003 | The Jungle Book 2 | $1,803,827 | Darkness Falls (#3), The Wild Thornberrys Movie (#8), Solaris (#10) |
| 16 | April 20, 2003 | $1,442,784 | Johnny English (#4) |
| 17 | April 27, 2003 | How to Lose a Guy in 10 Days | $1,094,239 | National Security (#7) |
| 18 | May 4, 2003 | X2: X-Men United | $4,988,709 | Asesino en serio (#2), Piglet's Big Movie (#5) |
| 19 | May 11, 2003 | $2,786,753 | Shanghai Knights (#4), Old School (#5) |
| 20 | May 18, 2003 | $1,855,579 | The Hunted (#2) |
| 21 | May 25, 2003 | The Matrix Reloaded | $5,814,951 | Pinocchio (#8) |
| 22 | June 1, 2003 | $3,021,546 | Bringing Down the House (#2), My Little Eye (#5), Chasing Papi (#7) |
| 23 | June 8, 2003 | Anger Management | $1,706,360 | The Emperor's Club (#8), Extreme Ops (#10) |
| 24 | June 15, 2003 | 2 Fast 2 Furious | $3,094,708 | Sin Ton ni Sonia (#2), Cradle 2 the Grave (#6) |
| 25 | June 22, 2003 | $1,942,592 | Daddy Day Care (#2), Phone Booth (#4), Dame tu Cuerpo (#5), Rugrats Go Wild (#6), Biker Boyz (#10) |
| 26 | June 29, 2003 | Hulk | $5,872,127 | Ripley's Game (#10) |
| 27 | July 6, 2003 | Finding Nemo | $7,002,432 | Boat Trip (#6), Drumline (#10) |
| 28 | July 13, 2003 | $4,382,470 | Charlie's Angels: Full Throttle (#2), Agent Cody Banks (#4), The Magdalene Sisters (#7) |
| 29 | July 20, 2003 | Bruce Almighty | $5,162,060 | Sinbad: Legend of the Seven Seas (#4) |
| 30 | July 27, 2003 | Terminator 3: Rise of the Machines | $4,649,456 | Legally Blonde 2: Red, White and Blonde (#5) |
| 31 | August 3, 2003 | Pirates of the Caribbean: The Curse of the Black Pearl | $4,234,902 | Avassaladoras (#10) |
| 32 | August 10, 2003 | $2,657,279 | Lara Croft Tomb Raider: The Cradle of Life (#3), Corazón de melón (#6), Holes (#8) |
| 33 | August 17, 2003 | $1,581,989 | Hollywood Homicide (#2), 28 Days Later (#4), What a Girl Wants (#5), A Man Apart (#8) |
| 34 | August 24, 2003 | The Italian Job | $1,193,050 | |
| 35 | August 31, 2003 | $932,490 | Down with Love (#4), Dumb and Dumberer: When Harry Met Lloyd (#10) |
| 36 | September 7, 2003 | American Wedding | $1,538,542 | Alex and Emma (#10) |
| 37 | September 14, 2003 | The League of Extraordinary Gentlemen | $2,839,399 | Bad Boys II (#2), The Lizzie McGuire Movie (#4), Spirited Away (#7) |
| 39 | September 21, 2003 | $1,643,613 | Freddy vs. Jason (#4), Confidence (#7) |
| 40 | September 28, 2003 | $1,088,954 | Matchstick Men (#3) |
| 41 | October 5, 2003 | Identity | $668,111 | Wrong Turn (#3) |
| 42 | October 12, 2003 | Spy Kids 3-D: Game Over | $2,241,899 | Basic (#2), El Otro Lado de la Cama (#8) |
| 43 | October 19, 2003 | $1,898,599 | S.W.A.T. (#2), Intolerable Cruelty (#3) |
| 44 | October 26, 2003 | $1,168,888 | Once Upon a Time in Mexico (#2), La Tregua (#7), Le Pacte du Silence (#9), Alien: The Director's Cut (#10) |
| 45 | November 2, 2003 | $848,576 | Jeepers Creepers 2 (#5), The Order (#6), The Medallion (#10) |
| 46 | November 9, 2003 | The Matrix Revolutions | $3,215,529 | Under the Tuscan Sun (#8) |
| 47 | November 16, 2003 | $1,786,160 | Runaway Jury (#2), Gigli (#9) |
| 48 | November 23, 2003 | 21 Grams | $1,756,494 | Freaky Friday (#2), Magos y Gigantes (#4) |
| 49 | November 30, 2003 | Looney Tunes: Back in Action | $1,452,493 | Kill Bill: Volume 1 (#4), The In-Laws (#6) |
| 50 | December 7, 2003 | $956,546 | The Cat in the Hat (#2), Mystic River (#6), Love Actually (#7) |
| 51 | December 14, 2003 | Ladies' Night | $1,554,028 | Stuck on You (#4), Beyond Borders (#10) |
| 52 | December 21, 2003 | The Lord of the Rings: The Return of the King | $5,134,776 | Brother Bear (#2) |
| 53 | December 28, 2003 | $3,948,747 | Mona Lisa Smile (#3), Elf (#5) |
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