USP25

USP25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MUX
Identifiers
Aliases	USP25, USP21, ubiquitin specific peptidase 25
External IDs	OMIM: 604736 MGI: 1353655 HomoloGene: 8374 GeneCards: USP25
Gene location (Human)
Chr.	Chromosome 21 (human)
End	15,880,064 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	76,913,668 bp
RNA expression pattern
	Top expressed in
	sperm; ; amniotic fluid; ; biceps brachii; ; Achilles tendon; ; gastrocnemius muscle; ; vastus lateralis muscle; ; deltoid muscle; ; thoracic diaphragm; ; tibialis anterior muscle; ; endothelial cell;
	Top expressed in
	knee joint; ; ciliary body; ; spermatid; ; blood; ; vastus lateralis muscle; ; esophagus; ; triceps brachii muscle; ; retinal pigment epithelium; ; conjunctival fornix; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase binding; peptidase activity; cysteine-type peptidase activity; ubiquitin binding; protein binding; hydrolase activity; ubiquitin protein ligase binding; thiol-dependent deubiquitinase; ubiquitin-like protein-specific protease activity; cysteine-type endopeptidase activity;
Cellular component	endoplasmic reticulum; nucleus; cytoplasm; cytosol;
Biological process	protein K63-linked deubiquitination; protein K48-linked deubiquitination; negative regulation of ERAD pathway; ubiquitin-dependent protein catabolic process; proteolysis; protein deubiquitination; regulation of protein stability;
	Sources:Amigo / QuickGO
Orthologs
	29761
	30940
	ENSG00000155313
	ENSMUSG00000022867
	Q9UHP3
	P57080
NM_001283041; NM_001283042; NM_013396; NM_001352560; NM_001352561;
	NM_001388299; NM_001388300; NM_001388301; NM_001388302
	NM_013918
	NP_001269970; NP_001269971; NP_037528; NP_001339489; NP_001339490
	NP_038946
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin specific peptidase 25 is a protein that in humans is encoded by the USP25 gene. ^[5]

Function[edit]

Ubiquitin is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008].

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155313 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022867 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ubiquitin specific peptidase 25". Retrieved 2017-10-31.

Further reading[edit]

Valero R, Bayés M, Francisca Sánchez-Font M, González-Angulo O, Gonzàlez-Duarte R, Marfany G (2001). "Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25". Genome Biol. 2 (10): RESEARCH0043. doi:10.1186/gb-2001-2-10-research0043. PMC 57798. PMID 11597335.
Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T (2008). "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer". Genes Chromosomes Cancer. 47 (9): 810–8. doi:10.1002/gcc.20582. PMID 18523997. S2CID 39369334.
Meulmeester E, Kunze M, Hsiao HH, Urlaub H, Melchior F (2008). "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25". Mol. Cell. 30 (5): 610–9. doi:10.1016/j.molcel.2008.03.021. hdl:11858/00-001M-0000-0012-DBA8-3. PMID 18538659.
Denuc A, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G (2009). "The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition". PLOS ONE. 4 (5): e5571. Bibcode:2009PLoSO...4.5571D. doi:10.1371/journal.pone.0005571. PMC 2679190. PMID 19440361.
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S (2010). "Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients". Inflamm. Bowel Dis. 16 (6): 907–9. doi:10.1002/ibd.21105. PMID 19760754.
Cholay M, Reverdy C, Benarous R, Colland F, Daviet L (2010). "Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase". Exp. Cell Res. 316 (4): 667–75. doi:10.1016/j.yexcr.2009.10.023. PMID 19909739.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Kessler BM, Edelmann MJ (2011). "PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications". Cell Biochem. Biophys. 60 (1–2): 21–38. doi:10.1007/s12013-011-9176-6. PMC 3094536. PMID 21480003.
Blount JR, Burr AA, Denuc A, Marfany G, Todi SV (2012). "Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation". PLOS ONE. 7 (5): e36542. Bibcode:2012PLoSO...736542B. doi:10.1371/journal.pone.0036542. PMC 3348923. PMID 22590560.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155313 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022867 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquitin specific peptidase 25". Retrieved 2017-10-31.

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USP25

Function[edit]

References[edit]

Further reading[edit]

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