Protein-coding gene in the species Homo sapiens
GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene .[5] [6] [7] [8]
Tissue specific transplantation antigen P35B is a NADP(H) -binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates , including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency , type II.[8]
References [ edit ] ^ a b c ENSG00000278243 GRCh38: Ensembl release 89: ENSG00000104522, ENSG00000278243 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022570 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B" . Blood . 85 (1): 264–7. doi :10.1182/blood.V85.1.264.bloodjournal851264 PMID 7803801 . ^ Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics . 35 (5): 316–23. doi :10.1007/bf00189894 . PMID 1348494 . S2CID 9048773 . ^ ^ a b "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B" . Further reading [ edit ] Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism" . J. Biol. Chem . 277 (5): 3168–75. doi :10.1074/jbc.M107927200 PMID 11698403 . Sullivan FX, Kumar R, Kriz R, et al. (1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro" . J. Biol. Chem . 273 (14): 8193–202. doi :10.1074/jbc.273.14.8193 PMID 9525924 . Tonetti M, Sturla L, Bisso A, et al. (1996). "Synthesis of GDP-L-fucose by the human FX protein" . J. Biol. Chem . 271 (44): 27274–9. doi :10.1074/jbc.271.44.27274 PMID 8910301 . External links [ edit ] PDBe-KB provides an overview of all the structure information available in the PDB for Human GDP-L-fucose synthase
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