Protein-coding gene in the species Homo sapiens
ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene .[5] [6]
ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns.[6]
Interactions [ edit ] ARF5 has been shown to interact with ARFIP2 .[7] [8]
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000004059 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020440 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M (March 1991). "Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells" . J Biol Chem . 266 (5): 2772–7. doi :10.1016/S0021-9258(18)49913-9 PMID 1993656 . ^ a b "Entrez Gene: ARF5 ADP-ribosylation factor 5" .^ Kanoh, H; Williger B T; Exton J H (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes" . J. Biol. Chem . 272 (9). UNITED STATES: 5421–9. doi :10.1074/jbc.272.9.5421 ISSN 0021-9258 . PMID 9038142 . ^ Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun . 285 (5). United States: 1267–73. doi :10.1006/bbrc.2001.5330 . ISSN 0006-291X . PMID 11478794 . External links [ edit ] Further reading [ edit ] Lee FJ, Moss J, Vaughan M (1992). "Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae" . J. Biol. Chem . 267 (34): 24441–5. doi :10.1016/S0021-9258(18)35786-7 PMID 1447192 . Stearns T, Willingham MC, Botstein D, Kahn RA (1990). "ADP-ribosylation factor is functionally and physically associated with the Golgi complex" . Proc. Natl. Acad. Sci. U.S.A . 87 (3): 1238–42. Bibcode :1990PNAS...87.1238S . doi :10.1073/pnas.87.3.1238 PMC 53446 PMID 2105501 . Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature . 364 (6439): 732–4. Bibcode :1993Natur.364..732O . doi :10.1038/364732a0 . PMID 8355790 . S2CID 4348442 . Helms JB, Palmer DJ, Rothman JE (1993). "Two distinct populations of ARF bound to Golgi membranes" . J. Cell Biol . 121 (4): 751–60. doi :10.1083/jcb.121.4.751 . PMC 2119793 PMID 8491770 . Kanoh H, Williger BT, Exton JH (1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes" . J. Biol. Chem . 272 (9): 5421–9. doi :10.1074/jbc.272.9.5421 PMID 9038142 . McGuire RE, Daiger SP, Green ED (1997). "Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene" . Genomics . 41 (3): 481–4. doi :10.1006/geno.1997.4689 . PMID 9169151 . Andreev J, Simon JP, Sabatini DD, et al. (1999). "Identification of a New Pyk2 Target Protein with Arf-GAP Activity" . Mol. Cell. Biol . 19 (3): 2338–50. doi :10.1128/MCB.19.3.2338 . PMC 84026 PMID 10022920 . Honda A, Nogami M, Yokozeki T, et al. (1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation" . Cell . 99 (5): 521–32. doi :10.1016/S0092-8674(00)81540-8 PMID 10589680 . S2CID 10031591 . Shin OH, Ross AH, Mihai I, Exton JH (2000). "Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors" . J. Biol. Chem . 274 (51): 36609–15. doi :10.1074/jbc.274.51.36609 PMID 10593962 . Kondo A, Hashimoto S, Yano H, et al. (2000). "A New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment to Focal Adhesions and Cell Migration" . Mol. Biol. Cell . 11 (4): 1315–27. doi :10.1091/mbc.11.4.1315 . PMC 14849 PMID 10749932 . Nevrivy DJ, Peterson VJ, Avram D, et al. (2000). "Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors" . J. Biol. Chem . 275 (22): 16827–36. doi :10.1074/jbc.275.22.16827 PMID 10828067 . Shin OH, Couvillon AD, Exton JH (2001). "Arfophilin is a common target of both class II and class III ADP-ribosylation factors". Biochemistry . 40 (36): 10846–52. doi :10.1021/bi0107391 . PMID 11535061 . Austin C, Boehm M, Tooze SA (2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry . 41 (14): 4669–77. doi :10.1021/bi016064j . PMID 11926829 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology" . Science . 300 (5620): 767–72. Bibcode :2003Sci...300..767S . doi :10.1126/science.1083423 . PMC 2882961 PMID 12690205 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
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