5-HT1A受体

5-HT1A受體
識別號
别名	HTR1A；, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A
外部ID	OMIM：109760 MGI：96273 HomoloGene：20148 GeneCards：HTR1A
為以下藥物的標靶
	氟班色林、frovatriptan、LP-12、LP-211、LP-44、1-naphthylpiperazine、5-carboxamidotryptamine、血清素、8-OH-DPAT、阿立哌唑、bmy-14802、過乳降、氯氮平、CP-93129、donitriptan、eletriptan、EMDT、flesinoxan、麥角乙脲、LSD、LY293284、LY334370、那法道曲、那拉曲坦、F-15599、ocaperidone、奥氮平、喹硫平、quinpirole、利扎曲坦、ru-24969、S-14506、S-14671、spiroxatrine、舒马曲坦、坦度螺酮、U92016A、呫诺美林、zalospirone、佐米曲普坦、阿樸嗎啡、BMY-7378、brl-15572、溴隱亭、丁螺環酮、fluparoxan、gr-127935、伊沙匹隆、培高利特、吡貝地爾、roxindole、S-15535、sb-216641、特麦角脲、维拉佐酮、沃替西汀、齊拉西酮、布他拉莫、氯丙嗪、cyamemazine、fluspirilene、氟哌啶醇、iloperidone、apiose、酮色林、mesoridazine、metitepine、NAN 190、匹莫齊特、吲哚洛尔、酰胺哌啶酮、苯噻啶、raclopride、repinotan、利培酮、ritanserin、robalzotan、sertindole、spiperone、thioridazine、tiospirone、WAY-100135、WAY-100635、育亨宾、zotepine、xaliproden、齐美定、aripiprazole lauroxil、吉哌隆、buspirone hydrochloride
基因位置（人类）
染色体	5號染色體
终止	63,962,507 bp
基因位置（小鼠）
染色体	小鼠13号染色体
终止	105,584,630 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled receptor activity; • signal transducer activity; • G protein-coupled serotonin receptor activity; • 血浆蛋白结合; • serotonin binding; • neurotransmitter receptor activity; • receptor-receptor interaction;
細胞組分	• integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • 树突;
生物學過程	• G protein-coupled receptor signaling pathway; • regulation of behavior; • 血管收縮; • adenylate cyclase-inhibiting serotonin receptor signaling pathway; • serotonin metabolic process; • behavioral fear response; • regulation of dopamine metabolic process; • regulation of serotonin secretion; • 探究行为; • serotonin receptor signaling pathway; • positive regulation of cell population proliferation; • regulation of hormone secretion; • 細胞增殖; • 訊息傳遞; • 动物行为; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • 化学性突触传递;
	Sources:Amigo / QuickGO
直系同源
	3350
	15550
	ENSG00000178394
	ENSMUSG00000021721
	P08908
	Q64264
	NM_000524
	NM_008308
	NP_000515
	NP_032334
	維基數據
檢視/編輯人類	檢視/編輯小鼠

5-HT_1A受体是血清素受体的一种，可与神经递质血清素（5-HT）结合。它可以在脑、脾和新生儿肾脏中表达。它是一种G蛋白偶联受体（GPCR），可与Gi蛋白（英语：Gi alpha subunit）偶联，在脑中的激活可介导超极化和突触后神经元放电率降低。人的5-HT_1A受体由HTR1A基因编码。^[6]^[7]

参考文献

^ 對5-HT1A受體起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000178394 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000021721 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ. Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. Genomics. November 1989, 5 (4): 940–4. PMC 3154173 . PMID 2591972. doi:10.1016/0888-7543(89)90138-9.
^ Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A.

外部链接

5-HT_1A. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. [2008-11-24]. （原始内容存档于2012-09-02）.
Human HTR1A genome location and HTR1A gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[1] 對5-HT1A受體起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000178394 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000021721 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2591972-6] Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ. Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. Genomics. November 1989, 5 (4): 940–4. PMC 3154173 . PMID 2591972. doi:10.1016/0888-7543(89)90138-9.

[entrez-7] Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A.

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5-HT1A受体

参考文献

外部链接

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