肝細胞増殖因子

HGF
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧

1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J, 4O3T, 4O3U, 5COE, 5CP9, 5CS1, 5CS3, 5CS5, 5CS9, 5CSQ, 5CT1, 5CT2, 5CT3, 4D3C

識別子
記号HGF, DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor
外部IDOMIM: 142409 MGI: 96079 HomoloGene: 503 GeneCards: HGF
遺伝子の位置 (ヒト)
7番染色体 (ヒト)
染色体7番染色体 (ヒト)[1]
7番染色体 (ヒト)
HGF遺伝子の位置
HGF遺伝子の位置
バンドデータ無し開始点81,699,010 bp[1]
終点81,770,438 bp[1]
遺伝子の位置 (マウス)
5番染色体 (マウス)
染色体5番染色体 (マウス)[2]
5番染色体 (マウス)
HGF遺伝子の位置
HGF遺伝子の位置
バンドデータ無し開始点16,758,493 bp[2]
終点16,825,150 bp[2]
RNA発現パターン




さらなる参照発現データ
遺伝子オントロジー
分子機能 血漿タンパク結合
identical protein binding
chemoattractant activity
protein heterodimerization activity
growth factor activity
serine-type endopeptidase activity
protein tyrosine kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
細胞の構成要素
細胞外領域
platelet alpha granule lumen
細胞外空間
生物学的プロセス negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of neuron projection regeneration
positive regulation of interleukin-10 production
positive regulation of cell migration
cellular response to hepatocyte growth factor stimulus
negative regulation of release of cytochrome c from mitochondria
negative regulation of interleukin-6 production
platelet degranulation
negative regulation of apoptotic process
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
positive regulation of angiogenesis
positive regulation of myelination
positive regulation of osteoblast differentiation
myoblast proliferation
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
animal organ regeneration
cell morphogenesis
positive regulation of cell population proliferation
hyaluronan metabolic process
positive regulation of DNA biosynthetic process
negative regulation of peptidyl-serine phosphorylation
上皮間葉転換
positive regulation of peptidyl-tyrosine phosphorylation
cell chemotaxis
肝臓発生
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of p38MAPK cascade
細胞増殖
negative regulation of autophagy
hepatocyte growth factor receptor signaling pathway
negative regulation of inflammatory response
positive regulation of transcription by RNA polymerase II
regulation of tau-protein kinase activity
タンパク質分解
positive chemotaxis
MAPK cascade
peptidyl-tyrosine phosphorylation
phosphatidylinositol phosphate biosynthetic process
体細胞分裂
regulation of signaling receptor activity
positive regulation of protein kinase B signaling
positive regulation of protein phosphorylation
サイトカイン媒介シグナル伝達経路
epithelial cell proliferation
出典:Amigo / QuickGO
オルソログ
ヒトマウス
Entrez
Ensembl
UniProt
RefSeq
(mRNA)

NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934

NM_010427
NM_001289458
NM_001289459
NM_001289460
NM_001289461

RefSeq
(タンパク質)

NP_000592
NP_001010931
NP_001010932
NP_001010933
NP_001010934

NP_001276387
NP_001276388
NP_001276389
NP_001276390
NP_034557

場所
(UCSC)
Chr 7: 81.7 – 81.77 MbChr 7: 16.76 – 16.83 Mb
PubMed検索[3][4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

肝細胞増殖因子(かんさいぼうぞうしょくいんし、HGF: Hepatocyte growth factorまたはSF: scatter factor)は、分子量が約9万の一本鎖のタンパク質。

HGF activator (HGFA)と呼ばれるセリンプロテアーゼにより分子量約6万のα鎖と約3万のβ鎖に切断されると生理活性を発現する。

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000019991 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028864 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference: