Carcinoma squamo-cellulare di Marjolin

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Carcinoma squamo-cellulare di Marjolin
Specialitàoncologia e chirurgia
Classificazione e risorse esterne (EN)
ICD-10C44.L12
Modifica dati su Wikidata · Manuale

Il carcinoma squamo-cellulare di Marjolin o ulcera di Marjolin è un tumore maligno della cute che può insorgere raramente in aree cutanee già colpite da ulcere,[1][2] o da gravi ustioni.[3][4] L'incidenza lifetime di questa neoplasia è attorno all'1-2% nei soggetti con ulcere croniche di vecchia data o con esiti cicatriziali di ustioni subdermiche [5][6]

Storia[modifica | modifica wikitesto]

Il primo riscontro in letteratura risale al 1903 in un lavoro di J.C. Da Costa che indicò come ulcera di Marjolin una ulcera venosa degenerata.[7]

Eziologia[modifica | modifica wikitesto]

Il processo per cui si viene ad instaurare questa forma di tumore maligno è poco chiara; si è a conoscenza del fatto che il tumore si sviluppa in aree di cute in cui vi è una cronicità della lesione. Il periodo di latenza, ossia da quando inizia l'evento traumatico e il manifestarsi del tumore, è abbastanza lungo (alcuni autori parlano di 20-32 anni) ed è inversamente proporzionale all'età; questo incide sulla formulazione di una diagnosi tempestiva.

Diagnosi[modifica | modifica wikitesto]

La biopsia è il metodo favorito di diagnosi. Campioni di tessuto dovrebbero essere estratti dal centro e il margine della lesione, così come dalle zone ulcerate e zone necrotiche.

Trattamento[modifica | modifica wikitesto]

Si predilige il trattamento chirurgico; si rimuove la lesione completamente e circa un centimetro di bordo sano attorno all'ulcerazione. La radio-terapia è un'alternativa di trattamento non invasivo che ha dato soddisfacenti esiti in molti casi.

Prognosi[modifica | modifica wikitesto]

Il tumore data la sua aggressività ha un alto grado di mortalità:[8] 4 casi su 5.

Note[modifica | modifica wikitesto]

  1. ^ Esther RJ, Lamps L, Schwartz HS, Marjolin ulcers: secondary carcinomas in chronic wounds, in J South Orthop Assoc, vol. 8, n. 3, 1999, pp. 181–7, PMID 12132863.
  2. ^ Simmons MA, Edwards JM, Nigam A, Marjolin's ulcer presenting in the neck, in J Laryngol Otol, vol. 114, n. 12, dicembre 2000, pp. 980–2, PMID 11177375.
  3. ^ Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  4. ^ Phillips TJ, Salman SM, Bhawan J, Rogers GS, Burn scar carcinoma. Diagnosis and management, in Dermatol Surg, vol. 24, n. 5, maggio 1998, pp. 561–5, DOI:10.1016/S1076-0512(98)00022-3, PMID 9598012.
  5. ^ Dariusz Bazaliński, Joanna Przybek-Mita e Beata Barańska, Marjolin's ulcer in chronic wounds - review of available literature, in Contemporary Oncology (Poznan, Poland), vol. 21, n. 3, 2017, pp. 197–202, DOI:10.5114/wo.2017.70109. URL consultato il 15 maggio 2021.
  6. ^ Eray Copcu, Marjolin's ulcer: a preventable complication of burns?, in Plastic and Reconstructive Surgery, vol. 124, n. 1, 2009-07, pp. 156e–164e, DOI:10.1097/PRS.0b013e3181a8082e. URL consultato il 15 maggio 2021.
  7. ^ Riforma medica: giornale internazionale settimanale de medicina, chirurgia e scienze affini, 1985.
  8. ^ AJ. Chong, MB. Klein, Images in clinical medicine. Marjolin's ulcer., in N Engl J Med, vol. 352, n. 10, marzo 2005, pp. e9, DOI:10.1056/NEJMicm040020, PMID 15758002.

Bibliografia[modifica | modifica wikitesto]

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  • Rodríguez Anguiano Jorge Iván, Alba Laguna Eva Miriam, Mauro Ibarra Juana Yadira, Romo Sánchez Manuel Gabriel, Muñóz Camacho José Guadalupe, Molina Cárdenas Hugo Roberto. Úlcera de Marjolin. Presentación de un caso y revisión de la literatura Med Int Mex 2002; 18(2): 106-109.
  • http://www.dermato.med.br/ufrj2005/%DAlcera%20de%20Marjolin%20com%20met%E1stase%20cut%E2nea.pdf[collegamento interrotto]

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