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40S ribosomal protein S12

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesRPS12, S12, ribosomal protein S12
External IDsOMIM: 603660 MGI: 98105 HomoloGene: 110750 GeneCards: RPS12
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RPS12
Genomic location for RPS12
Band6q23.2Start132,814,569 bp[1]
End132,817,564 bp[1]
RNA expression pattern
PBB GE RPS12 213377 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 132.81 – 132.82 Mbn/a
PubMed search[2][3]
View/Edit HumanView/Edit Mouse

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.[4][5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112306 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res. 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC 328500. PMID 1861993.
  5. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  6. ^ a b "Entrez Gene: RPS12 ribosomal protein S12".

Further reading[edit]

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