Protein-coding gene in the species Homo sapiens
cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene .[3] [4] [5]
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit .[5]
Interactions [ edit ] PRKACG has been shown to interact with Ryanodine receptor 2 .[6]
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000165059 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase" . Mol Endocrinol . 4 (3): 465–75. doi :10.1210/mend-4-3-465 PMID 2342480 . ^ Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics . 49 (2): 290–7. doi :10.1006/geno.1998.5240 . PMID 9598317 . ^ a b "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma" .^ Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts" . Cell . 101 (4). UNITED STATES: 365–76. doi :10.1016/S0092-8674(00)80847-8 ISSN 0092-8674 . PMID 10830164 . S2CID 6496567 . Further reading [ edit ] Foss KB, Simard J, Bérubé D, Beebe S, Sandberg M, Grzeschik KH, Gagné R, Hansson V, Jahnsen T (1992). "Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13". Cytogenet. Cell Genet . 60 (1): 22–5. doi :10.1159/000133286 . PMID 1339328 . Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism" . J. Immunol . 145 (11): 3699–705. doi :10.4049/jimmunol.145.11.3699 PMID 1978848 . Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes" . Proc. Natl. Acad. Sci. U.S.A . 90 (14): 6676–80. Bibcode :1993PNAS...90.6676H . doi :10.1073/pnas.90.14.6676 PMC 46995 PMID 7688126 . Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS . 8 (7): 1016–7. doi :10.1097/00002030-199407000-00025 . PMID 7946090 . Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix" . J. Virol . 71 (6): 4372–7. doi :10.1128/JVI.71.6.4372-4377.1997 . PMC 191654 PMID 9151826 . Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases" . J. Biol. Chem . 272 (36): 22385–8. doi :10.1074/jbc.272.36.22385 PMID 9278385 . Liapi C, Takahashi N, Raynaud F, Evain-Brion D, Anderson WB (1998). "Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts" . J. Invest. Dermatol . 110 (4): 332–7. doi :10.1046/j.1523-1747.1998.00149.x PMID 9540970 . Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses . 14 (10): 825–33. doi :10.1089/aid.1998.14.825 . PMID 9671211 . Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation . 5 (3–4): 184–92. doi :10.1159/000026336 . PMID 9730685 . S2CID 19529677 . Bodnar RJ, Xi X, Li Z, Berndt MC, Du X (2003). "Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta)" . J. Biol. Chem . 277 (49): 47080–7. doi :10.1074/jbc.M208329200 PMID 12361948 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cartier C, Hemonnot B, Gay B, Bardy M, Sanchiz C, Devaux C, Briant L (2003). "Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein" . J. Biol. Chem . 278 (37): 35211–9. doi :10.1074/jbc.M301257200 PMID 12842892 . Masci AM, Galgani M, Cassano S, De Simone S, Gallo A, De Rosa V, Zappacosta S, Racioppi L (2004). "HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling" . J. Leukoc. Biol . 74 (6): 1117–24. doi :10.1189/jlb.0503239 PMID 12972513 . S2CID 13393007 . Zhang W, Morris GZ, Beebe SJ (2004). "Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells". Protein Expr. Purif . 35 (1): 156–69. doi :10.1016/j.pep.2004.01.006 . PMID 15039079 . Stevanin G, Hahn V, Lohmann E, Bouslam N, Gouttard M, Soumphonphakdy C, Welter ML, Ollagnon-Roman E, Lemainque A (2004). "Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14" . Arch. Neurol . 61 (8): 1242–8. doi :10.1001/archneur.61.8.1242 PMID 15313841 . Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
Activity Regulation Classification Kinetics Types
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