Jumping translocation breakpoint

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Jumping translocation breakpoint protein (JTB)
Jumping translocation breakpoint protein (JTB)
Identifiers
Symbol	JTB
Pfam	PF05439
InterPro	IPR008657
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

JTB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KJX
Identifiers
Aliases	JTB, HHSPC222, PAR, hJT, jumping translocation breakpoint
External IDs	OMIM: 604671 MGI: 1346082 HomoloGene: 4870 GeneCards: JTB
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,977,674 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,143,145 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; tibia; ; pancreatic ductal cell; ; body of pancreas; ; pituitary gland; ; anterior pituitary; ; periodontal fiber; ; bronchial epithelial cell; ; palpebral conjunctiva; ; tibialis anterior muscle;
	Top expressed in
	parotid gland; ; saccule; ; seminal vesicula; ; Paneth cell; ; lacrimal gland; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; digastric muscle; ; temporal muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase binding;
Cellular component	cytoplasm; integral component of membrane; centrosome; spindle; midbody; integral component of plasma membrane; cytoskeleton; membrane; mitochondrion; microtubule organizing center;
Biological process	apoptotic process; cell division; cell cycle; apoptotic mitochondrial changes; regulation of cell population proliferation; positive regulation of protein kinase activity; mitotic cell cycle; mitotic cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	10899
	23922
	ENSG00000143543
	ENSMUSG00000027937
	O76095
	O88824
	NM_006694
	NM_206924
	NP_006685
	NP_996807
	Wikidata
View/Edit Human	View/Edit Mouse

The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.^[5]^[6] It is an orphan receptor with unknown function.^[7]

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC).^[5] JTB has also been implicated in prostatic carcinomas.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143543 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027937 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Hatakeyama S, Osawa M, Omine M, Ishikawa F (Jun 1999). "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation". Oncogene. 18 (12): 2085–90. doi:10.1038/sj.onc.1202510. PMID 10321732.
^ "Entrez Gene: JTB jumping translocation breakpoint".
^ Rousseau, Francois; Pan, Borlan; Fairbrother, Wayne J.; Bazan, J. Fernando; Lingel, Andreas (January 2012). "The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold". Journal of Molecular Biology. 415 (1): 22–28. doi:10.1016/j.jmb.2011.10.048. PMID 22079049.
^ Platica O, Chen S, Ivan E, Lopingco MC, Holland JF, Platica M (May 2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645.

External links[edit]

PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein JTB

This article incorporates text from the public domain Pfam and InterPro: IPR008657

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143543 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027937 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10321732-5] Hatakeyama S, Osawa M, Omine M, Ishikawa F (Jun 1999). "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation". Oncogene. 18 (12): 2085–90. doi:10.1038/sj.onc.1202510. PMID 10321732.

[entrez-6] "Entrez Gene: JTB jumping translocation breakpoint".

[7] Rousseau, Francois; Pan, Borlan; Fairbrother, Wayne J.; Bazan, J. Fernando; Lingel, Andreas (January 2012). "The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold". Journal of Molecular Biology. 415 (1): 22–28. doi:10.1016/j.jmb.2011.10.048. PMID 22079049.

[pmid10762645-8] Platica O, Chen S, Ivan E, Lopingco MC, Holland JF, Platica M (May 2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645.

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Jumping translocation breakpoint

References[edit]

Further reading[edit]

External links[edit]

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