File:Merkel Cell Carcinoma buttock 45-year-old woman.jpg
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Summary
| Description | This large tumor presented as a protuberant mass on the buttock of a 45-year-old woman. Microscopically it showed sheets of undifferentiated cells with high nuclear/cytoplasmic ratio, a high mitotic rate, a occasional inconspicuous nucleoli. Immunostains showed strong dot-like and diffuse cytoplasmic positivity for cytokeratins 20, CAM5.2, and AE1-AE3, as well as granular staining for synaptophysin and chromogranin. There were negative reactions for cytokeratin 7, gross cystic disease fluid protein 15, melan-A, S-100 protein, and thyroid transcription factor 1-alpha. Even though the histologic features and immunostain profile was characteristic of a primary skin tumor, the presentation is atypical. Usually, Merkel cell carcinoma presents on the sun-exposed areas of elderly individuals. Therefore, the pathologist recommended workup for the possibility of another primary site, including lung, female genital tract, salivary gland, and other cutaneous site. |
| Date | |
| Source | Merkel Cell Carcinoma |
| Author | Ed Uthman from Houston, TX, USA |
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 | This image was originally posted to Flickr by euthman at https://www.flickr.com/photos/78147607@N00/414633167. It was reviewed on 13 April 2008 by FlickreviewR and was confirmed to be licensed under the terms of the cc-by-sa-2.0. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:04, 9 April 2008 | | 3,286 × 2,824 (2.72 MB) | Jacopo Werther | {{Information |Description= This large tumor presented as a protuberant mass on the buttock of a 45-year-old woman. Microscopically it showed sheets of undifferentiated cells with high nuclear/cytoplasmic ratio, a high mitotic rate, a occasional inconspic |
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