Chromosome 6 open reading frame 203

From Wikipedia the free encyclopedia

MTRES1
Identifiers
AliasesMTRES1, PRED31, HSPC230, chromosome 6 open reading frame 203, mitochondrial transcription rescue factor 1, C6orf203
External IDsMGI: 1915101 HomoloGene: 41137 GeneCards: MTRES1
Orthologs
SpeciesHumanMouse
Entrez

51250

67851

Ensembl

ENSG00000130349

ENSMUSG00000019797

UniProt

Q9P0P8

Q9CQF4

RefSeq (mRNA)

NM_001142468
NM_001142470
NM_016487

NM_026411

RefSeq (protein)

NP_001135940
NP_001135942
NP_057571

NP_080687

Location (UCSC)Chr 6: 107.03 – 107.05 MbChr 10: 43.4 – 43.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromosome 6 open reading frame 203 is a protein that in humans is encoded by the C6orf203 gene. [5]

C6orf203 protein is reported to be localised to the mitochondria of eukaryotes and possess an evolutionarily conserved RNA-binding domain.[6][7]

One study propose C6orf203 to associate with mitochondrial RNA polymerase (POLRMT) and increase mitochondrial transcription to protect the cell from mitochondrial RNA loss during stress.[7] However, another study propose C6orf203 to associate with the mitoribosomal large subunit and regulate mitochondrial translation.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130349 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019797 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Chromosome 6 open reading frame 203". Retrieved 2018-05-11.
  6. ^ a b Gopalakrishna S, Pearce SF, Dinan AM, Schober FA, Cipullo M, Spåhr H, et al. (August 2019). "C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis". Nucleic Acids Research. 47 (17): 9386–9399. doi:10.1093/nar/gkz684. PMC 6755124. PMID 31396629.
  7. ^ a b Kotrys AV, Cysewski D, Czarnomska SD, Pietras Z, Borowski LS, Dziembowski A, Szczesny RJ (June 2019). "Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria". Nucleic Acids Research. 47 (14): 7502–7517. doi:10.1093/nar/gkz542. PMC 6698753. PMID 31226201.

Further reading[edit]


Stub icon

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Chromosome_6_open_reading_frame_203&oldid=1177907638"