Post | Minister | Term | Party |
| President of South Africa | His Excellency Cyril Ramaphosa | 2018 | – | ANC |
| Deputy President of South Africa | His Excellency David Mabuza | 2018 | – | ANC |
| Minister of Planning, Monitoring and Evaluation in the Presidency | The Hon. Nkosazana Dlamini-Zuma MP | 2018 | 2019 | ANC |
| Minister of Women in the Presidency | The Hon. Bathabile Dlamini MP | 2018 | 2019 | ANC |
| Minister of Agriculture, Forestry and Fisheries | The Hon. Senzeni Zokwana MP | 2014 | 2019 | ANC |
| Minister of Arts and Culture | The Hon. Nathi Mthethwa MP | 2014 | 2019 | ANC |
| Minister of Basic Education | The Hon. Angie Motshekga MP | 2009 | – | ANC |
| Minister of Communications | The Hon. Stella Ndabeni-Abrahams MP | 2018 | 2021 | ANC |
| Minister of Cooperative Governance and Traditional Affairs | The Hon. Zweli Mkhize MP | 2018 | 2019 | ANC |
| Minister of Defence and Military Veterans | The Hon. Nosiviwe Mapisa-Nqakula MP | 2012 | 2021 | ANC |
| Minister of Economic Development | The Hon. Ebrahim Patel MP | 2009 | 2019 | ANC |
| Minister of Energy | The Hon. Jeff Radebe MP | 2018 | 2019 | ANC |
| Minister of Environmental Affairs | The Hon. Nomvula Mokonyane MP | 2018 | 2019 | ANC |
| Minister of Finance | The Hon. Tito Mboweni | 2018 | 2021 | ANC |
| Minister of Health | The Hon. Aaron Motsoaledi MP | 2009 | 2019 | ANC |
| Minister of Higher Education and Training | The Hon. Naledi Pandor MP | 2018 | 2019 | ANC |
| Minister of Home Affairs | The Hon. Siyabonga Cwele MP | 2018 | 2019 | ANC |
| Minister of Human Settlements | The Hon. Nomaindia Mfeketo MP | 2018 | 2019 | ANC |
| Minister of International Relations and Cooperation | The Hon. Lindiwe Sisulu MP | 2018 | 2019 | ANC |
| Minister of Labour | The Hon. Mildred Oliphant MP | 2018 | 2019 | ANC |
| Minister of Mineral Resources | The Hon. Gwede Mantashe MP | 2018 | – | ANC |
| Minister of Police | The Hon. Bheki Cele MP | 2018 | – | ANC |
| Minister of Public Enterprises | The Hon. Pravin Gordhan MP | 2018 | – | ANC |
| Minister of Public Service and Administration | The Hon. Ayanda Dlodlo MP | 2018 | 2019 | ANC |
| Minister of Public Works | The Hon. Thulas Nxesi MP | 2018 | 2019 | ANC |
| Minister of Rural Development and Land Reform | The Hon. Maite Nkoana-Mashabane MP | 2018 | 2019 | ANC |
| Minister of Science and Technology | The Hon. Mmamoloko Kubayi-Ngubane MP | 2018 | 2019 | ANC |
| Minister of Small Business Development | The Hon. Lindiwe Zulu MP | 2014 | 2019 | ANC |
| Minister of Social Development | The Hon. Susan Shabangu MP | 2018 | 2019 | ANC |
| Minister of Sport and Recreation | The Hon. Tokozile Xasa MP | 2018 | 2019 | ANC |
| Minister of State Security | The Hon. Dipuo Letsatsi-Duba MP | 2018 | 2019 | ANC |
| Minister of Tourism | The Hon. Derek Hanekom MP | 2018 | 2019 | ANC |
| Minister of Trade and Industry | The Hon. Rob Davies MP | 2009 | 2019 | ANC |
| Minister of Transport | The Hon. Blade Nzimande MP | 2018 | 2019 | ANC |
| Minister of Water and Sanitation | The Hon. Gugile Nkwinti MP | 2018 | 2019 | ANC |